Lazio should be the clear favourites in this matchup based on overall squad quality, tactical discipline, and the obvious difference in level between the two sides. Playing at home gives them even more control, especially in a match where they are expected to dominate possession and create the majority of chances.
Pisa can be competitive and organised, but against a side with Lazio’s attacking depth and technical quality, sustaining defensive resistance for 90 minutes is a huge challenge. The pace and movement in Lazio’s forward areas should create enough openings sooner or later.
Matches like this often come down to quality and efficiency, and Lazio simply have more of both. Unless they massively underperform, the home win is the logical angle.